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Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase 3 in colon cancer cells

We have previously shown that the death receptor ligand TRAIL induces an increase in intracellular C(16)-ceramide in sensitive SW480 but not in resistant SW620 cells. Resistance in SW620 cells was overcome by exogenous ceramide leading us to propose that defective ceramide signaling contributes to T...

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Detalles Bibliográficos
Autores principales:	White-Gilbertson, S., Mullen, T., Senkal, C., Lu, P., Ogretmen, B., Obeid, L., Voelkel-Johnson, C.
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648838/ https://www.ncbi.nlm.nih.gov/pubmed/19137010 http://dx.doi.org/10.1038/onc.2008.468

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