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Genome-Scale Reconstruction of Escherichia coli's Transcriptional and Translational Machinery: A Knowledge Base, Its Mathematical Formulation, and Its Functional Characterization

Metabolic network reconstructions represent valuable scaffolds for ‘-omics’ data integration and are used to computationally interrogate network properties. However, they do not explicitly account for the synthesis of macromolecules (i.e., proteins and RNA). Here, we present the first genome-scale,...

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Detalles Bibliográficos
Autores principales: Thiele, Ines, Jamshidi, Neema, Fleming, Ronan M. T., Palsson, Bernhard Ø.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648898/
https://www.ncbi.nlm.nih.gov/pubmed/19282977
http://dx.doi.org/10.1371/journal.pcbi.1000312