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Statistical independence of the colocalized association signals for type 1 diabetes and RPS26 gene expression on chromosome 12q13

Following the recent success of genome-wide association studies in uncovering disease-associated genetic variants, the next challenge is to understand how these variants affect downstream pathways. The most proximal trait to a disease-associated variant, most commonly a single nucleotide polymorphis...

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Detalles Bibliográficos
Autores principales: Plagnol, Vincent, Smyth, Deborah J., Todd, John A., Clayton, David G.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648905/
https://www.ncbi.nlm.nih.gov/pubmed/19039033
http://dx.doi.org/10.1093/biostatistics/kxn039