Detergent resistant membrane-associated IDE in brain tissue and cultured cells: Relevance to Aβ and insulin degradation

BACKGROUND: Insulin degrading enzyme (IDE) is implicated in the regulation of amyloid β (Aβ) steady-state levels in the brain, and its deficient expression and/or activity may be a risk factor in sporadic Alzheimer's disease (AD). Although IDE sub-cellular localization has been well studied, th...

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Detalles Bibliográficos
Autores principales: Bulloj, Ayelén, Leal, María C, Surace, Ezequiel I, Zhang, Xue, Xu, Huaxi, Ledesma, Maria D, Castaño, Eduardo M, Morelli, Laura
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648957/
https://www.ncbi.nlm.nih.gov/pubmed/19117523
http://dx.doi.org/10.1186/1750-1326-3-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648957/
https://www.ncbi.nlm.nih.gov/pubmed/19117523
http://dx.doi.org/10.1186/1750-1326-3-22

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