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Detergent resistant membrane-associated IDE in brain tissue and cultured cells: Relevance to Aβ and insulin degradation
BACKGROUND: Insulin degrading enzyme (IDE) is implicated in the regulation of amyloid β (Aβ) steady-state levels in the brain, and its deficient expression and/or activity may be a risk factor in sporadic Alzheimer's disease (AD). Although IDE sub-cellular localization has been well studied, th...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648957/ https://www.ncbi.nlm.nih.gov/pubmed/19117523 http://dx.doi.org/10.1186/1750-1326-3-22 |