5-Fluorotryptamine is a partial agonist at 5-HT(3) receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function

Antagonists, but not agonists, of the 5-HT(3) receptor are useful therapeutic agents, and it is possible that partial agonists may also be potentially useful in the clinic. Here we show that 5-fluorotryptamine (5-FT) is a partial agonist at both 5-HT(3A) and 5-HT(3AB) receptors with an R(max) (I(max...

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Detalles Bibliográficos
Autores principales: Bower, Kiowa S., Price, Kerry L., Sturdee, Laura E.C., Dayrell, Mariza, Dougherty, Dennis A., Lummis, Sarah C.R.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649378/
https://www.ncbi.nlm.nih.gov/pubmed/18082160
http://dx.doi.org/10.1016/j.ejphar.2007.11.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649378/
https://www.ncbi.nlm.nih.gov/pubmed/18082160
http://dx.doi.org/10.1016/j.ejphar.2007.11.014

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