Silencing of PINK1 Expression Affects Mitochondrial DNA and Oxidative Phosphorylation in DOPAMINERGIC Cells

BACKGROUND: Mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD). Impairment of the mitochondrial electron transport chain (ETC) and an increased frequency in deletions of mitochondrial DNA (mtDNA), which encodes some of the subunits of the ETC, have bee...

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Detalles Bibliográficos
Autores principales: Gegg, Matthew E., Cooper, J. Mark, Schapira, Anthony H. V., Taanman, Jan-Willem
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649444/
https://www.ncbi.nlm.nih.gov/pubmed/19270741
http://dx.doi.org/10.1371/journal.pone.0004756

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649444/
https://www.ncbi.nlm.nih.gov/pubmed/19270741
http://dx.doi.org/10.1371/journal.pone.0004756

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