Modeling Signal Propagation Mechanisms and Ligand-Based Conformational Dynamics of the Hsp90 Molecular Chaperone Full-Length Dimer

Hsp90 is a molecular chaperone essential for protein folding and activation in normal homeostasis and stress response. ATP binding and hydrolysis facilitate Hsp90 conformational changes required for client activation. Hsp90 plays an important role in disease states, particularly in cancer, where cha...

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Detalles Bibliográficos
Autores principales: Morra, Giulia, Verkhivker, Gennady, Colombo, Giorgio
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649446/
https://www.ncbi.nlm.nih.gov/pubmed/19300478
http://dx.doi.org/10.1371/journal.pcbi.1000323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649446/
https://www.ncbi.nlm.nih.gov/pubmed/19300478
http://dx.doi.org/10.1371/journal.pcbi.1000323

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