Lung Epithelial Injury by B. Anthracis Lethal Toxin Is Caused by MKK-Dependent Loss of Cytoskeletal Integrity

Bacillus anthracis lethal toxin (LT) is a key virulence factor of anthrax and contributes significantly to the in vivo pathology. The enzymatically active component is a Zn(2+)-dependent metalloprotease that cleaves most isoforms of mitogen-activated protein kinase kinases (MKKs). Using ex vivo diff...

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Detalles Bibliográficos
Autores principales: Lehmann, Mandy, Noack, Deborah, Wood, Malcolm, Perego, Marta, Knaus, Ulla G.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649448/
https://www.ncbi.nlm.nih.gov/pubmed/19270742
http://dx.doi.org/10.1371/journal.pone.0004755

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649448/
https://www.ncbi.nlm.nih.gov/pubmed/19270742
http://dx.doi.org/10.1371/journal.pone.0004755

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