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Nanomole-scale Protein Solid-state NMR by Breaking Intrinsic (1)H-T(1) Boundaries
We present an approach that speeds up protein solid-state NMR (SSNMR) by 5–20 fold by using paramagnetic doping to condense data-collection time (to ~0.2 s/scan), overcoming a long-standing limitation on slow recycling due to intrinsic (1)H T(1) longitudinal spin relaxation. By employing low-power s...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649701/ https://www.ncbi.nlm.nih.gov/pubmed/19198596 http://dx.doi.org/10.1038/nmeth.1300 |