Proteomics-based Identification of Novel Factor Inhibiting Hypoxia-inducible Factor (FIH) Substrates Indicates Widespread Asparaginyl Hydroxylation of Ankyrin Repeat Domain-containing Proteins

Post-translational hydroxylation has been considered an unusual modification on intracellular proteins. However, following the recognition that oxygen-sensitive prolyl and asparaginyl hydroxylation are central to the regulation of the transcription factor hypoxia-inducible factor (HIF), interest has...

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Detalles Bibliográficos
Autores principales: Cockman, Matthew E., Webb, James D., Kramer, Holger B., Kessler, Benedikt M., Ratcliffe, Peter J.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649815/
https://www.ncbi.nlm.nih.gov/pubmed/18936059
http://dx.doi.org/10.1074/mcp.M800340-MCP200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649815/
https://www.ncbi.nlm.nih.gov/pubmed/18936059
http://dx.doi.org/10.1074/mcp.M800340-MCP200

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