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A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci

There is considerable variability in the susceptibility of smokers to develop chronic obstructive pulmonary disease (COPD). The only known genetic risk factor is severe deficiency of α(1)-antitrypsin, which is present in 1–2% of individuals with COPD. We conducted a genome-wide association study (GW...

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Hlavní autoři: Pillai, Sreekumar G., Ge, Dongliang, Zhu, Guohua, Kong, Xiangyang, Shianna, Kevin V., Need, Anna C., Feng, Sheng, Hersh, Craig P., Bakke, Per, Gulsvik, Amund, Ruppert, Andreas, Lødrup Carlsen, Karin C., Roses, Allen, Anderson, Wayne, Rennard, Stephen I., Lomas, David A., Silverman, Edwin K., Goldstein, David B.
Médium: Text
Jazyk:English
Vydáno: Public Library of Science 2009
Témata:
On-line přístup:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650282/
https://www.ncbi.nlm.nih.gov/pubmed/19300482
http://dx.doi.org/10.1371/journal.pgen.1000421