Mechanism of Werner DNA Helicase: POT1 and RPA Stimulates WRN to Unwind beyond Gaps in the Translocating Strand

WRN belongs to the RecQ family of DNA helicases and it plays a role in recombination, replication, telomere maintenance and long-patch base excision repair. Here, we demonstrate that WRN efficiently unwinds DNA substrates containing a 1-nucleotide gap in the translocating DNA strand, but when the ga...

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Detalles Bibliográficos
Autores principales: Ahn, Byungchan, Lee, Jae Wan, Jung, Hana, Beck, Gad, Bohr, Vilhelm A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650403/
https://www.ncbi.nlm.nih.gov/pubmed/19262689
http://dx.doi.org/10.1371/journal.pone.0004673

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650403/
https://www.ncbi.nlm.nih.gov/pubmed/19262689
http://dx.doi.org/10.1371/journal.pone.0004673

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