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Mechanism of Werner DNA Helicase: POT1 and RPA Stimulates WRN to Unwind beyond Gaps in the Translocating Strand
WRN belongs to the RecQ family of DNA helicases and it plays a role in recombination, replication, telomere maintenance and long-patch base excision repair. Here, we demonstrate that WRN efficiently unwinds DNA substrates containing a 1-nucleotide gap in the translocating DNA strand, but when the ga...
Autores principales: | Ahn, Byungchan, Lee, Jae Wan, Jung, Hana, Beck, Gad, Bohr, Vilhelm A. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650403/ https://www.ncbi.nlm.nih.gov/pubmed/19262689 http://dx.doi.org/10.1371/journal.pone.0004673 |
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