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Two Separate Interfaces between the Voltage Sensor and Pore Are Required for the Function of Voltage-Dependent K(+) Channels

Voltage-dependent K(+) (Kv) channels gate open in response to the membrane voltage. To further our understanding of how cell membrane voltage regulates the opening of a Kv channel, we have studied the protein interfaces that attach the voltage-sensor domains to the pore. In the crystal structure, th...

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Detalles Bibliográficos
Autores principales: Lee, Seok-Yong, Banerjee, Anirban, MacKinnon, Roderick
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650729/
https://www.ncbi.nlm.nih.gov/pubmed/19260762
http://dx.doi.org/10.1371/journal.pbio.1000047