Blood Stage Malaria Vaccine Eliciting High Antigen-Specific Antibody Concentrations Confers No Protection to Young Children in Western Kenya

OBJECTIVE: The antigen, falciparum malaria protein 1 (FMP1), represents the 42-kDa C-terminal fragment of merozoite surface protein-1 (MSP-1) of the 3D7 clone of P. falciparum. Formulated with AS02 (a proprietary Adjuvant System), it constitutes the FMP1/AS02 candidate malaria vaccine. We evaluated...

Descripción completa

Detalles Bibliográficos
Autores principales: Ogutu, Bernhards R., Apollo, Odika J., McKinney, Denise, Okoth, Willis, Siangla, Joram, Dubovsky, Filip, Tucker, Kathryn, Waitumbi, John N., Diggs, Carter, Wittes, Janet, Malkin, Elissa, Leach, Amanda, Soisson, Lorraine A., Milman, Jessica B., Otieno, Lucas, Holland, Carolyn A., Polhemus, Mark, Remich, Shon A., Ockenhouse, Christian F., Cohen, Joe, Ballou, W. Ripley, Martin, Samuel K., Angov, Evelina, Stewart, V. Ann, Lyon, Jeffrey A., Heppner, D. Gray, Withers, Mark R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650803/
https://www.ncbi.nlm.nih.gov/pubmed/19262754
http://dx.doi.org/10.1371/journal.pone.0004708

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650803/
https://www.ncbi.nlm.nih.gov/pubmed/19262754
http://dx.doi.org/10.1371/journal.pone.0004708

Ejemplares similares