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Active site substitutions delineate distinct classes of eubacterial flap endonuclease

FENs (flap endonucleases) play essential roles in DNA replication, pivotally in the resolution of Okazaki fragments. In eubacteria, DNA PolI (polymerase I) contains a flap processing domain, the N-terminal 5′→3′ exonuclease. We present evidence of paralogous FEN-encoding genes present in many eubact...

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Detalles Bibliográficos
Autores principales:	Allen, Lee M., Hodskinson, Michael R. G., Sayers, Jon R.
Formato:	Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650880/ https://www.ncbi.nlm.nih.gov/pubmed/19000038 http://dx.doi.org/10.1042/BJ20081637

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