Ras Conformational Switching: Simulating Nucleotide-Dependent Conformational Transitions with Accelerated Molecular Dynamics

Ras mediates signaling pathways controlling cell proliferation and development by cycling between GTP- and GDP-bound active and inactive conformational states. Understanding the complete reaction path of this conformational change and its intermediary structures is critical to understanding Ras sign...

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Detalles Bibliográficos
Autores principales: Grant, Barry J., Gorfe, Alemayehu A., McCammon, J. Andrew
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651530/
https://www.ncbi.nlm.nih.gov/pubmed/19300489
http://dx.doi.org/10.1371/journal.pcbi.1000325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651530/
https://www.ncbi.nlm.nih.gov/pubmed/19300489
http://dx.doi.org/10.1371/journal.pcbi.1000325

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