Uncoupling of the LKB1-AMPKα Energy Sensor Pathway by Growth Factors and Oncogenic BRAF(V600E)

BACKGROUND: Understanding the biochemical mechanisms contributing to melanoma development and progression is critical for therapeutical intervention. LKB1 is a multi-task Ser/Thr kinase that phosphorylates AMPK controlling cell growth and apoptosis under metabolic stress conditions. Additionally, LK...

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Detalles Bibliográficos
Autores principales: Esteve-Puig, Rosaura, Canals, Francesc, Colomé, Núria, Merlino, Glenn, Recio, Juan Ángel
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651576/
https://www.ncbi.nlm.nih.gov/pubmed/19274086
http://dx.doi.org/10.1371/journal.pone.0004771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651576/
https://www.ncbi.nlm.nih.gov/pubmed/19274086
http://dx.doi.org/10.1371/journal.pone.0004771

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