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Interactions between Casein Kinase Iε (CKIε) and Two Substrates from Disparate Signaling Pathways Reveal Mechanisms for Substrate-Kinase Specificity

BACKGROUND: Members of the Casein Kinase I (CKI) family of serine/threonine kinases regulate diverse biological pathways. The seven mammalian CKI isoforms contain a highly conserved kinase domain and divergent amino- and carboxy-termini. Although they share a preferred target recognition sequence an...

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Detalles Bibliográficos
Autores principales: Dahlberg, Caroline Lund, Nguyen, Elizabeth Z., Goodlett, David, Kimelman, David
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651596/
https://www.ncbi.nlm.nih.gov/pubmed/19274088
http://dx.doi.org/10.1371/journal.pone.0004766