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Mechanistic Insight into the Role of Transition-State Stabilization in Cyclophilin A
[Image: see text] Peptidyl prolyl cis−trans isomerases (PPIases) are ubiquitous enzymes in biology that catalyze the cis−trans isomerization of the proline imide peptide bond in many cell signaling pathways. The local change of the isomeric state of the prolyl peptide bond acts as a switching mechan...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651649/ https://www.ncbi.nlm.nih.gov/pubmed/19128175 http://dx.doi.org/10.1021/ja806146g |