Structures of Falcipain-2 and Falcipain-3 Bound to Small Molecule Inhibitors: Implications for Substrate Specificity

[Image: see text] Falcipain-2 and falcipain-3 are critical hemoglobinases of Plasmodium falciparum, the most virulent human malaria parasite. We have determined the 2.9 Å crystal structure of falcipain-2 in complex with the epoxysuccinate E64 and the 2.5 Å crystal structure of falcipain-3 in complex...

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Detalles Bibliográficos
Autores principales: Kerr, Iain D., Lee, Ji H., Pandey, Kailash C., Harrison, Amanda, Sajid, Mohammed, Rosenthal, Philip J., Brinen, Linda S.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2009
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651692/
https://www.ncbi.nlm.nih.gov/pubmed/19128015
http://dx.doi.org/10.1021/jm8013663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651692/
https://www.ncbi.nlm.nih.gov/pubmed/19128015
http://dx.doi.org/10.1021/jm8013663

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