A bridged nucleic acid, 2′,4′-BNA(COC): synthesis of fully modified oligonucleotides bearing thymine, 5-methylcytosine, adenine and guanine 2′,4′-BNA(COC) monomers and RNA-selective nucleic-acid recognition

Recently, we synthesized pyrimidine derivatives of the 2′-O,4′-C-methylenoxymethylene-bridged nucleic-acid (2′,4′-BNA(COC)) monomer, the sugar conformation of which is restricted in N-type conformation by a seven-membered bridged structure. Oligonucleotides (BNA(COC)) containing this monomer show hi...

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Detalles Bibliográficos
Autores principales: Mitsuoka, Yasunori, Kodama, Tetsuya, Ohnishi, Ryo, Hari, Yoshiyuki, Imanishi, Takeshi, Obika, Satoshi
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Chemistry and Synthetic Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651773/
https://www.ncbi.nlm.nih.gov/pubmed/19136459
http://dx.doi.org/10.1093/nar/gkn1062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651773/
https://www.ncbi.nlm.nih.gov/pubmed/19136459
http://dx.doi.org/10.1093/nar/gkn1062

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