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Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions

The wobble modification in tRNAs, 5-methoxycarbonylmethyl-2-thiouridine (mcm(5)s(2)U), is required for the proper decoding of NNR codons in eukaryotes. The 2-thio group confers conformational rigidity of mcm(5)s(2)U by largely fixing the C3′-endo ribose puckering, ensuring stable and accurate codon–...

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Detalles Bibliográficos
Autores principales: Noma, Akiko, Sakaguchi, Yuriko, Suzuki, Tsutomu
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651780/
https://www.ncbi.nlm.nih.gov/pubmed/19151091
http://dx.doi.org/10.1093/nar/gkn1023