The N-terminal PIN domain of the exosome subunit Rrp44 harbors endonuclease activity and tethers Rrp44 to the yeast core exosome

Nuclear and cytoplasmic forms of the yeast exosome share 10 components, of which only Rrp44/Dis3 is believed to possess 3′ exonuclease activity. We report that expression only of Rrp44 lacking 3′-exonuclease activity (Rrp44-exo) supports growth in S288c-related strains (BY4741). In BY4741, rrp44-exo...

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Detalles Bibliográficos
Autores principales: Schneider, Claudia, Leung, Eileen, Brown, Jeremy, Tollervey, David
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651783/
https://www.ncbi.nlm.nih.gov/pubmed/19129231
http://dx.doi.org/10.1093/nar/gkn1020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651783/
https://www.ncbi.nlm.nih.gov/pubmed/19129231
http://dx.doi.org/10.1093/nar/gkn1020

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