Synthesis and characterization of 2′-modified-4′-thioRNA: a comprehensive comparison of nuclease stability

We report herein the synthesis and physical and physiological characterization of fully modified 2′-modified-4′-thioRNAs, i.e. 2′-fluoro-4′-thioRNA (F-SRNA) and 2′-O-Me-4′-thioRNA (Me-SRNA), which can be considered as a hybrid chemical modification based on 2′-modified oligonucleotides (ONs) and 4′-...

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Detalles Bibliográficos
Autores principales: Takahashi, Mayumi, Minakawa, Noriaki, Matsuda, Akira
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Chemistry and Synthetic Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651785/
https://www.ncbi.nlm.nih.gov/pubmed/19151085
http://dx.doi.org/10.1093/nar/gkn1088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651785/
https://www.ncbi.nlm.nih.gov/pubmed/19151085
http://dx.doi.org/10.1093/nar/gkn1088

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