A novel approach for organelle-specific DNA damage targeting reveals different susceptibility of mitochondrial DNA to the anticancer drugs camptothecin and topotecan

DNA is susceptible of being damaged by chemicals, UV light or gamma irradiation. Nuclear DNA damage invokes both a checkpoint and a repair response. By contrast, little is known about the cellular response to mitochondrial DNA damage. We designed an experimental system that allows organelle-specific...

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Detalles Bibliográficos
Autores principales: de la Loza, M. C. Díaz, Wellinger, R. E.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651790/
https://www.ncbi.nlm.nih.gov/pubmed/19151088
http://dx.doi.org/10.1093/nar/gkn1087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651790/
https://www.ncbi.nlm.nih.gov/pubmed/19151088
http://dx.doi.org/10.1093/nar/gkn1087

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