Inhibition of HIV-1 gene expression by Sam68ΔC: multiple targets but a common mechanism?

Two recent publications have explored the mechanisms by which a mutant of the host protein Sam68 blocks HIV-1 structural protein synthesis and expands its activity to encompass Nef. Although the two studies propose different mechanisms for the responses observed, it is possible that a common activit...

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Detalles Bibliográficos
Autor principal: Cochrane, Alan
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651844/
https://www.ncbi.nlm.nih.gov/pubmed/19254361
http://dx.doi.org/10.1186/1742-4690-6-22
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author Cochrane, Alan
author_facet Cochrane, Alan
author_sort Cochrane, Alan
collection PubMed
description Two recent publications have explored the mechanisms by which a mutant of the host protein Sam68 blocks HIV-1 structural protein synthesis and expands its activity to encompass Nef. Although the two studies propose different mechanisms for the responses observed, it is possible that a common activity is responsible. Understanding how this Sam68 mutant discriminates among the multiple viral mRNAs promises to reveal unique properties of HIV-1 RNA metabolism.
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spelling pubmed-26518442009-03-06 Inhibition of HIV-1 gene expression by Sam68ΔC: multiple targets but a common mechanism? Cochrane, Alan Retrovirology Commentary Two recent publications have explored the mechanisms by which a mutant of the host protein Sam68 blocks HIV-1 structural protein synthesis and expands its activity to encompass Nef. Although the two studies propose different mechanisms for the responses observed, it is possible that a common activity is responsible. Understanding how this Sam68 mutant discriminates among the multiple viral mRNAs promises to reveal unique properties of HIV-1 RNA metabolism. BioMed Central 2009-03-02 /pmc/articles/PMC2651844/ /pubmed/19254361 http://dx.doi.org/10.1186/1742-4690-6-22 Text en Copyright © 2009 Cochrane; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Cochrane, Alan
Inhibition of HIV-1 gene expression by Sam68ΔC: multiple targets but a common mechanism?
title Inhibition of HIV-1 gene expression by Sam68ΔC: multiple targets but a common mechanism?
title_full Inhibition of HIV-1 gene expression by Sam68ΔC: multiple targets but a common mechanism?
title_fullStr Inhibition of HIV-1 gene expression by Sam68ΔC: multiple targets but a common mechanism?
title_full_unstemmed Inhibition of HIV-1 gene expression by Sam68ΔC: multiple targets but a common mechanism?
title_short Inhibition of HIV-1 gene expression by Sam68ΔC: multiple targets but a common mechanism?
title_sort inhibition of hiv-1 gene expression by sam68δc: multiple targets but a common mechanism?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651844/
https://www.ncbi.nlm.nih.gov/pubmed/19254361
http://dx.doi.org/10.1186/1742-4690-6-22
work_keys_str_mv AT cochranealan inhibitionofhiv1geneexpressionbysam68dcmultipletargetsbutacommonmechanism

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