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Using multiplexed regulation of luciferase activity and GFP translocation to screen for FOXO modulators
BACKGROUND: Independent luciferase reporter assays and fluorescent translocation assays have been successfully used in drug discovery for several molecular targets. We developed U2transLUC, an assay system in which luciferase and fluorescent read-outs can be multiplexed to provide a powerful cell-ba...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651847/ https://www.ncbi.nlm.nih.gov/pubmed/19243599 http://dx.doi.org/10.1186/1471-2121-10-14 |