Sample size requirements to detect the effect of a group of genetic variants in case-control studies

BACKGROUND: Because common diseases are caused by complex interactions among many genetic variants along with environmental risk factors, very large sample sizes are usually needed to detect such effects in case-control studies. Nevertheless, many genetic variants act in well defined biologic system...

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Detalles Bibliográficos
Autores principales: Moonesinghe, Ramal, Yang, Quanhe, Khoury, Muin J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Analytic Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651869/
https://www.ncbi.nlm.nih.gov/pubmed/19055767
http://dx.doi.org/10.1186/1742-7622-5-24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651869/
https://www.ncbi.nlm.nih.gov/pubmed/19055767
http://dx.doi.org/10.1186/1742-7622-5-24

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