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Sample size requirements to detect the effect of a group of genetic variants in case-control studies
BACKGROUND: Because common diseases are caused by complex interactions among many genetic variants along with environmental risk factors, very large sample sizes are usually needed to detect such effects in case-control studies. Nevertheless, many genetic variants act in well defined biologic system...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651869/ https://www.ncbi.nlm.nih.gov/pubmed/19055767 http://dx.doi.org/10.1186/1742-7622-5-24 |