Incorporating double copies of a chromatin insulator into lentiviral vectors results in less viral integrants

BACKGROUND: Lentiviral vectors hold great promise as gene transfer vectors in gene therapeutic settings. However, problems related to the risk of insertional mutagenesis, transgene silencing and positional effects have stalled the use of such vectors in the clinic. Chromatin insulators are boundary...

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Detalles Bibliográficos
Autores principales: Nielsen, Troels T, Jakobsson, Johan, Rosenqvist, Nina, Lundberg, Cecilia
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651870/
https://www.ncbi.nlm.nih.gov/pubmed/19239708
http://dx.doi.org/10.1186/1472-6750-9-13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651870/
https://www.ncbi.nlm.nih.gov/pubmed/19239708
http://dx.doi.org/10.1186/1472-6750-9-13

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