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Incorporating double copies of a chromatin insulator into lentiviral vectors results in less viral integrants
BACKGROUND: Lentiviral vectors hold great promise as gene transfer vectors in gene therapeutic settings. However, problems related to the risk of insertional mutagenesis, transgene silencing and positional effects have stalled the use of such vectors in the clinic. Chromatin insulators are boundary...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651870/ https://www.ncbi.nlm.nih.gov/pubmed/19239708 http://dx.doi.org/10.1186/1472-6750-9-13 |