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The Mechanism of Folding of Im7 Reveals Competition between Functional and Kinetic Evolutionary Constraints
Many proteins reach their native state through pathways involving the presence of folding intermediates. It is not clear whether this type of folding landscape results from insufficient evolutionary pressure to optimize folding efficiency, or arises from a conflict between functional and folding con...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651959/ https://www.ncbi.nlm.nih.gov/pubmed/19252485 http://dx.doi.org/10.1038/nsmb.1562 |