Structural Lability in Stem–Loop 1 Drives a 5′ UTR–3′ UTR Interaction in Coronavirus Replication

The leader RNA of the 5′ untranslated region (UTR) of coronaviral genomes contains two stem–loop structures denoted SL1 and SL2. Herein, we show that SL1 is functionally and structurally bipartite. While the upper region of SL1 is required to be paired, we observe strong genetic selection against vi...

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Detalles Bibliográficos
Autores principales: Li, Lichun, Kang, Hyojeung, Liu, Pinghua, Makkinje, Nick, Williamson, Shawn T., Leibowitz, Julian L., Giedroc, David P.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652258/
https://www.ncbi.nlm.nih.gov/pubmed/18289557
http://dx.doi.org/10.1016/j.jmb.2008.01.068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652258/
https://www.ncbi.nlm.nih.gov/pubmed/18289557
http://dx.doi.org/10.1016/j.jmb.2008.01.068

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