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The HLA-DRα Chain Is Modified by Polyubiquitination
Ubiquitination plays a major role in regulating cell surface and intracellular localization of major histocompatibility complex class II molecules. Two E3 ligases, MARCH I and MARCH VIII, have been shown to polyubiquitinate lysine residue 225 in the cytoplasmic tail of I-Aβ and HLA-DRβ. We show that...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652342/ https://www.ncbi.nlm.nih.gov/pubmed/19117940 http://dx.doi.org/10.1074/jbc.M805736200 |