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Transcriptional Infidelity Promotes Heritable Phenotypic Change in a Bistable Gene Network

Bistable epigenetic switches are fundamental for cell fate determination in unicellular and multicellular organisms. Regulatory proteins associated with bistable switches are often present in low numbers and subject to molecular noise. It is becoming clear that noise in gene expression can influence...

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Detalles Bibliográficos
Autores principales: Gordon, Alasdair J. E, Halliday, Jennifer A, Blankschien, Matthew D, Burns, Philip A, Yatagai, Fumio, Herman, Christophe
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652393/
https://www.ncbi.nlm.nih.gov/pubmed/19243224
http://dx.doi.org/10.1371/journal.pbio.1000044