Point mutation of tyrosine 759 of the IL-6 family cytokine receptor, gp130, augments collagen-induced arthritis in DBA/1J mice

BACKGROUND: Knock-in mice (gp130F759) with a Y759F point mutation in gp130, a signal transducing receptor subunit shared by members of the IL-6 cytokine family, show sustained activation of STAT3, enhanced acute-phase or immune responses, and autoimmune arthritis. We conducted a detailed analysis of...

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Detalles Bibliográficos
Autores principales: Tsuji, Fumio, Yoshimi, Miwa, Katsuta, Osamu, Takai, Miwa, Ishihara, Katsuhiko, Aono, Hiroyuki
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652421/
https://www.ncbi.nlm.nih.gov/pubmed/19228423
http://dx.doi.org/10.1186/1471-2474-10-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652421/
https://www.ncbi.nlm.nih.gov/pubmed/19228423
http://dx.doi.org/10.1186/1471-2474-10-23

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