Chemical Probes that Competitively and Selectively Inhibit Stat3 Activation

Signal transducer and activator of transcription (Stat) 3 is an oncogene constitutively activated in many cancer systems where it contributes to carcinogenesis. To develop chemical probes that selectively target Stat3, we virtually screened 920,000 small drug-like compounds by docking each into the...

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Detalles Bibliográficos
Autores principales: Xu, Xuejun, Kasembeli, Moses M., Jiang, Xueqing, Tweardy, Benjamin J., Tweardy, David J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653189/
https://www.ncbi.nlm.nih.gov/pubmed/19274102
http://dx.doi.org/10.1371/journal.pone.0004783

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653189/
https://www.ncbi.nlm.nih.gov/pubmed/19274102
http://dx.doi.org/10.1371/journal.pone.0004783

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