Cargando…

Chemical Probes that Competitively and Selectively Inhibit Stat3 Activation

Signal transducer and activator of transcription (Stat) 3 is an oncogene constitutively activated in many cancer systems where it contributes to carcinogenesis. To develop chemical probes that selectively target Stat3, we virtually screened 920,000 small drug-like compounds by docking each into the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Xuejun, Kasembeli, Moses M., Jiang, Xueqing, Tweardy, Benjamin J., Tweardy, David J.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653189/ https://www.ncbi.nlm.nih.gov/pubmed/19274102 http://dx.doi.org/10.1371/journal.pone.0004783

Ejemplares similares

Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment
por: Kasembeli, Moses M., et al.
Publicado: (2018)

Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma
por: Bharadwaj, Uddalak, et al.
Publicado: (2016)

Correction: Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma
por: Bharadwaj, Uddalak, et al.
Publicado: (2019)

TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain
por: Kasembeli, Moses M., et al.
Publicado: (2021)

Monoclonal Antibodies Specific for STAT3β Reveal Its Contribution to Constitutive STAT3 Phosphorylation in Breast Cancer
por: Bharadwaj, Uddalak, et al.
Publicado: (2014)

Aberrant function of pathogenic STAT3 mutant proteins is linked to altered stability of monomers and homodimers
por: Kasembeli, Moses M., et al.
Publicado: (2023)

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution
por: Bharadwaj, Uddalak, et al.
Publicado: (2020)

Modulation of STAT3 Folding and Function by TRiC/CCT Chaperonin
por: Kasembeli, Moses, et al.
Publicado: (2014)

Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis
por: Roh, Soung-Hun, et al.
Publicado: (2015)

Substance P Receptor Signaling Mediates Doxorubicin-Induced Cardiomyocyte Apoptosis and Triple-Negative Breast Cancer Chemoresistance
por: Robinson, Prema, et al.
Publicado: (2016)

DRUG-REPOSITIONING SCREENING IDENTIFIED PIPERLONGUMINE AS A DIRECT STAT3 INHIBITOR WITH POTENT ACTIVITY AGAINST BREAST CANCER
por: Bharadwaj, Uddalak, et al.
Publicado: (2014)

Prevention of Hypovolemic Circulatory Collapse by IL-6 Activated Stat3
por: Alten, Jeffrey A., et al.
Publicado: (2008)

Genetic and Small-Molecule Modulation of Stat3 in a Mouse Model of Crohn’s Disease
por: Robinson, Prema, et al.
Publicado: (2022)

Correction: Prevention of Hypovolemic Circulatory Collapse by IL-6 Activated Stat3
por: Alten, Jeffrey A., et al.
Publicado: (2008)

IL-6-Mediated Activation of Stat3α Prevents Trauma/Hemorrhagic Shock-Induced Liver Inflammation
por: Moran, Ana, et al.
Publicado: (2011)

Spatial molecular and cellular determinants of STAT3 activation in liver fibrosis progression in non-alcoholic fatty liver disease
por: Jiao, Jingjing, et al.
Publicado: (2022)

Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species(†)
por: Yuan, Hengjie, et al.
Publicado: (2015)

Therapeutic Potential of a Small-Molecule STAT3 Inhibitor in a Mouse Model of Colitis
por: Robinson, Prema, et al.
Publicado: (2023)

Correction: Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species(†)
por: Yuan, Hengjie, et al.
Publicado: (2016)

Selective Small Molecule Stat3 Inhibitor Reduces Breast Cancer Tumor-Initiating Cells and Improves Recurrence Free Survival in a Human-Xenograft Model
por: Dave, Bhuvanesh, et al.
Publicado: (2012)

Correction: Selective Small Molecule Stat3 Inhibitor Reduces Breast Cancer Tumor-Initiating Cells and Improves Recurrence Free Survival in a Human-Xenograft Model
por: Dave, Bhuvanesh, et al.
Publicado: (2012)

Why CEnR Matters for Health Equity
por: Fagan, Heather Bittner, et al.
Publicado: (2018)

A mix of S and ΔS variants of STAT3 enable survival of activated B-cell-like diffuse large B-cell lymphoma cells in culture
por: Zheng, M, et al.
Publicado: (2016)

Modulation of the Unfolded Protein Response During Hepatocyte and Cardiomyocyte Apoptosis In Trauma/Hemorrhagic Shock
por: Thacker, Stephen A., et al.
Publicado: (2013)

Substance P Signaling Contributes to Granuloma Formation in Taenia crassiceps Infection, a Murine Model of Cysticercosis
por: Garza, Armandina, et al.
Publicado: (2010)

Signal Transducer and Activator of Transcription-3 Modulation of Cardiac Pathology in Chronic Chagasic Cardiomyopathy
por: Hoffman, Kristyn A., et al.
Publicado: (2021)

Remote Monitoring of Vital and Activity Parameters in Chronic Transfusion-Dependent Patients: A Feasibility Pilot Using Wearable Biosensors
por: Tonino, Rik Paulus Bernardus, et al.
Publicado: (2022)

Monitoring GAPDH activity and inhibition with cysteine-reactive chemical probes
por: Canarelli, Sarah E., et al.
Publicado: (2022)

Substance P Causes Seizures in Neurocysticercosis
por: Robinson, Prema, et al.
Publicado: (2012)

Chemical probes for competitive profiling of the quorum sensing signal synthase PqsD of Pseudomonas aeruginosa
por: Prothiwa, Michaela, et al.
Publicado: (2016)

Chemical probes and inhibitors of bromodomains outside the BET family
por: Moustakim, Moses, et al.
Publicado: (2016)

A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective
por: Ong, Han Wee, et al.
Publicado: (2023)

The Chemical Probes Portal: an expert review-based public resource to empower chemical probe assessment, selection and use
por: Antolin, Albert A, et al.
Publicado: (2022)

Discovery of an MLLT1/3 YEATS Domain Chemical Probe
por: Moustakim, Moses, et al.
Publicado: (2018)

Somatostatin Negatively Regulates Parasite Burden and Granulomatous Responses in Cysticercosis
por: Khumbatta, Mitra, et al.
Publicado: (2014)

Corrigendum to “Somatostatin Negatively Regulates Parasite Burden and Granulomatous Responses in Cysticercosis”
por: Khumbatta, Mitra, et al.
Publicado: (2015)

Eriocalyxin B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3
por: Yu, Xiaokui, et al.
Publicado: (2015)

Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective
por: Ong, Han Wee, et al.
Publicado: (2023)

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition
por: Frost, Julianty, et al.
Publicado: (2016)

GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain
por: Bamborough, Paul, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_4aac3qeoucn1vnqahu7igvd51e