The Werner Syndrome Helicase/Exonuclease Processes Mobile D-Loops through Branch Migration and Degradation

RecQ DNA helicases are critical for preserving genome integrity. Of the five RecQ family members identified in humans, only the Werner syndrome protein (WRN) possesses exonuclease activity. Loss of WRN causes the progeroid disorder Werner syndrome which is marked by cancer predisposition. Cellular e...

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Detalles Bibliográficos
Autores principales: Opresko, Patricia L., Sowd, Gregory, Wang, Hong
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653227/
https://www.ncbi.nlm.nih.gov/pubmed/19283071
http://dx.doi.org/10.1371/journal.pone.0004825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653227/
https://www.ncbi.nlm.nih.gov/pubmed/19283071
http://dx.doi.org/10.1371/journal.pone.0004825

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