STAT2 hypomorphic mutant mice display impaired dendritic cell development and antiviral response

Interferons (IFNs) are key regulators for both innate and adaptive immune responses. By screening ENU-mutagenized mice, we identified a pedigree- P117 which displayed impaired response to type I, but not type II, IFNs. Through inheritance test, genetic mapping and sequencing, we found a T to A point...

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Detalles Bibliográficos
Autores principales: Chen, Lan-Sun, Wei, Pei-Chi, Liu, Taming, Kao, Chung-Hsuan, Pai, Li-Mei, Lee, Chien-Kuo
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653529/
https://www.ncbi.nlm.nih.gov/pubmed/19272190
http://dx.doi.org/10.1186/1423-0127-16-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653529/
https://www.ncbi.nlm.nih.gov/pubmed/19272190
http://dx.doi.org/10.1186/1423-0127-16-22

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