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STAT2 hypomorphic mutant mice display impaired dendritic cell development and antiviral response
Interferons (IFNs) are key regulators for both innate and adaptive immune responses. By screening ENU-mutagenized mice, we identified a pedigree- P117 which displayed impaired response to type I, but not type II, IFNs. Through inheritance test, genetic mapping and sequencing, we found a T to A point...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653529/ https://www.ncbi.nlm.nih.gov/pubmed/19272190 http://dx.doi.org/10.1186/1423-0127-16-22 |