Genistein-mediated inhibition of glycosaminoglycan synthesis, which corrects storage in cells of patients suffering from mucopolysaccharidoses, acts by influencing an epidermal growth factor-dependent pathway

BACKGROUND: Mucopolysaccharidoses (MPS) are inherited metabolic disorders caused by mutations leading to dysfunction of one of enzymes involved in degradation of glycosaminoglycans (GAGs). Due to their impaired degradation, GAGs accumulate in cells of patients, which results in dysfunction of tissue...

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Detalles Bibliográficos
Autores principales: Jakóbkiewicz-Banecka, Joanna, Piotrowska, Ewa, Narajczyk, Magdalena, Barańska, Sylwia, Węgrzyn, Grzegorz
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653532/
https://www.ncbi.nlm.nih.gov/pubmed/19272193
http://dx.doi.org/10.1186/1423-0127-16-26

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653532/
https://www.ncbi.nlm.nih.gov/pubmed/19272193
http://dx.doi.org/10.1186/1423-0127-16-26

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