Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy

Hypoxia-inducible factor-1 (HIF-1) has been reported to promote tumour radioresistance; therefore, it is recognised as an excellent target during radiation therapy. However, the inhibition of HIF-1 in unsuitable timing can suppress rather than enhance the effect of radiation therapy because its anti...

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Detalles Bibliográficos
Autores principales: Harada, H, Itasaka, S, Zhu, Y, Zeng, L, Xie, X, Morinibu, A, Shinomiya, K, Hiraoka, M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653764/
https://www.ncbi.nlm.nih.gov/pubmed/19223896
http://dx.doi.org/10.1038/sj.bjc.6604939

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653764/
https://www.ncbi.nlm.nih.gov/pubmed/19223896
http://dx.doi.org/10.1038/sj.bjc.6604939

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