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Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo
Histone deacetylation and DNA methylation have a central role in the control of gene expression in tumours, including transcriptional repression of tumour suppressor genes and genes involved in sensitivity to chemotherapy. Treatment of cisplatin-resistant cell lines with an inhibitor of DNA methyltr...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653770/ https://www.ncbi.nlm.nih.gov/pubmed/19259094 http://dx.doi.org/10.1038/sj.bjc.6604932 |