Aberrant Epigenetic Silencing Is Triggered by a Transient Reduction in Gene Expression

BACKGROUND: Aberrant epigenetic silencing plays a major role in cancer formation by inactivating tumor suppressor genes. While the endpoints of aberrant silencing are known, i.e., promoter region DNA methylation and altered histone modifications, the triggers of silencing are not known. We used the...

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Detalles Bibliográficos
Autores principales: Oyer, Jon A., Chu, Adrian, Brar, Sukhmani, Turker, Mitchell S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654015/
https://www.ncbi.nlm.nih.gov/pubmed/19279688
http://dx.doi.org/10.1371/journal.pone.0004832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654015/
https://www.ncbi.nlm.nih.gov/pubmed/19279688
http://dx.doi.org/10.1371/journal.pone.0004832

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