Cargando…
Aberrant Epigenetic Silencing Is Triggered by a Transient Reduction in Gene Expression
BACKGROUND: Aberrant epigenetic silencing plays a major role in cancer formation by inactivating tumor suppressor genes. While the endpoints of aberrant silencing are known, i.e., promoter region DNA methylation and altered histone modifications, the triggers of silencing are not known. We used the...
| Autores principales: | , , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654015/ https://www.ncbi.nlm.nih.gov/pubmed/19279688 http://dx.doi.org/10.1371/journal.pone.0004832 |