S9, a Novel Anticancer Agent, Exerts Its Anti-Proliferative Activity by Interfering with Both PI3K-Akt-mTOR Signaling and Microtubule Cytoskeleton

BACKGROUND: Deregulation of the phosphatidylinositol 3-kinases (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway plays a central role in tumor formation and progression, providing validated targets for cancer therapy. S9, a hybrid of α-methylene-γ-lactone and 2-phenyl indole compound, possesse...

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Detalles Bibliográficos
Autores principales: Zhang, Chao, Yang, Na, Yang, Chun-hao, Ding, Hua-sheng, Luo, Cheng, Zhang, Yu, Wu, Mao-jiang, Zhang, Xiong-wen, Shen, Xu, Jiang, Hua-liang, Meng, Ling-hua, Ding, Jian
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654064/
https://www.ncbi.nlm.nih.gov/pubmed/19293927
http://dx.doi.org/10.1371/journal.pone.0004881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654064/
https://www.ncbi.nlm.nih.gov/pubmed/19293927
http://dx.doi.org/10.1371/journal.pone.0004881

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