Role of 3′UTRs in the Translation of mRNAs Regulated by Oncogenic eIF4E—A Computational Inference

Eukaryotic cap-dependent mRNA translation is mediated by the initiation factor eIF4E, which binds mRNAs and stimulates efficient translation initiation. eIF4E is often overexpressed in human cancers. To elucidate the molecular signature of eIF4E target mRNAs, we analyzed sequence and structural prop...

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Detalles Bibliográficos
Autores principales: Santhanam, Arti N., Bindewald, Eckart, Rajasekhar, Vinagolu K., Larsson, Ola, Sonenberg, Nahum, Colburn, Nancy H., Shapiro, Bruce A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654073/
https://www.ncbi.nlm.nih.gov/pubmed/19290046
http://dx.doi.org/10.1371/journal.pone.0004868

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654073/
https://www.ncbi.nlm.nih.gov/pubmed/19290046
http://dx.doi.org/10.1371/journal.pone.0004868

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